The Missouri native, 45, had been with the company on and off since its inception in 2006, beginning his most recent stint as CEO in 2015.
The tech entrepreneur also shared his resignation letter with his nearly 6 million followers.
The philanthropist went on to say that he felt comforatble leaving the business in the hands of Parag Agrawal, who will replace him, and was confident in board chair Bret Taylor‘s leadership.
Last year, Twitter dealt with a serious hack that compromised the accounts of world leaders and business titans, including President Joe Biden, former President Barack Obama, Elon Musk and Bill Gates.
The company faced more drama earlier this year after permanently banning former President Donald Trump from the platform after the January 6 attack at the U.S.
After the ban, Dorsey said that he felt Twitter had made the “right decision,” adding that he was worried about the “precedent” it set.
According to The New York Times, however, Dorsey was not the person who made the call about banning Trump’s account — the decision was made by one of his employees because the then-CEO was away visiting French Polynesia.