McGuire, a successful longtime Texas high school coach, is in his fifth season at Baylor and his third as the team’s associate head coach.
“We are excited for this new chapter in Texas Tech Football under the direction of Coach McGuire,” director of athletics Kirby Hocutt said.
Texas Tech also considered Oklahoma defensive coordinator Alex Grinch, USC offensive coordinator and former Texas Tech quarterback Graham Harrell and others for the vacancy.