In a live-action setting it’s very difficult to imagine the likes of Superman and Spider-Man sharing the screen due to the logistical and contractual red tape that are notorious in Hollywood, but according to someone that would know, never say never.
Asked by a fan on Twitter if “there’s even a remote chance we ever see a big blockbuster crossover” between the two companies, Gunn replied: “I’ve casually talked to the powers-that-be at both Marvel & DC about it.
THAT SAID, just constantly seeing crossovers & mashups is less enchanting to me than a strong story.
In the 1990s would come the actual Marvel vs DC mini-series, written by Peter David and Ron Marz with art by Dan Jurgens and Claudio Castellini and featuring match-ups like Superman vs.
The two companies would crossover two more times, one with actual combinations in the Amalgam Universe like Princess Ororo of Themiscyra , and Kurt Busiek’s JLA/Avengers in 2003/2004.