Guice had been arrested on domestic violence charges in Loudoun County, Virginia, in August, stemming from three separate incidents earlier in 2020 at his home in Ashburn, Virginia.
Details of the settlement were not disclosed.
The running back has not played in the NFL since being cut by Washington.
According to multiple reports, two other women have alleged the same and a third accused Guice of sharing a partially nude photo of her without consent.