Sherman will now be out at least three weeks after suffering a calf injury during pregame warmups prior to the Week 10 loss to Washington.
The 33-year-old is just two years removed from his most recent Pro Bowl season that also saw him help the 49ers advance to the Super Bowl.
The Buccaneers have dealt with several injuries to their secondary this season, as Carlton Davis and Sean Murphy-Bunting are currently on injured reserve.