He gave up four earned runs, including two home runs to two of the NL’s best hitters in Joey Votto and Nick Castellanos.
Didi Gregorius’ 2-for-4 game with two doubles saved the Phillies from getting shutout for the second time this week.
Following a Castellanos hit-by-pitch, Votto launched his sixth career home run at Citizens Bank Park to give the Reds a 3-0 lead.
Friday was Wheeler’s first outing in which he has surrendered multiple home runs in a game since April 20.