The Toronto-born R&B superstar won for best artist and best album during a virtual telecast on the CBC network.
The Canadian-born superstar also won for best pop album for Changes after being nominated for five Juno awards this year, including Juno fan choice, single of the year, album of the year, artist of the year and pop album of the year.
The Juno Fan Choice Award, presented by Canadian actor Will Arnett and The Basement Gang, went for the third time to Shawn Mendes.
Elsewhere on Sunday night, Toronto artist Savannah Re won for best traditional R&B/soul recording for “Solid,” and JP Saxe was named the best breakthrough artist on Sunday night.
Mary Piercey-Lewis was named as the Musicounts Teacher of the year for her work at the Inuksuk High School in Iqaluit, Nunavut, in Canada’s far north.
Other Juno presenters included Sarah McLachlan, Alessia Cara, Kaytranada, Michael Bublé, Shania Twain, Geddy Lee and Alex Lifeson of Rush.
And, oddly enough, I am also very grateful for the ones who did not, because they only served to make me stronger,” Arden said while accepting her honor.
On Friday night, in other earlier prize giving, JJ Wilde won for best rock album for Ruthless — the first woman to win in that category since 1996 when Alanis Morissette won best rock album for Jagged Little Pill.
This year’s Juno Awards included Ali Gatie and Tate McCrae singing duets for “Lie to Me” and “What If I Told You That I Loved You” from Los Angeles, Jessie Reyez singing “Do You Love Her” and “Before Love Came to Kill Us,” again from Los Angeles.